Regulation of SNAP-25 trafficking and function by palmitoylation.

نویسندگان

  • Jennifer Greaves
  • Gerald R Prescott
  • Oforiwa A Gorleku
  • Luke H Chamberlain
چکیده

The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking and exocytotic function of this essential protein.

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 38 Pt 1  شماره 

صفحات  -

تاریخ انتشار 2010